HUMAN PLACENTA Substrate, liquid (1.5 mg/mL)

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HUMAN PLACENTA Substrate (hpS)

Comprising highly purified ECM and bioactive proteins, prepared from placenta basal tissue of individuals that have been shown by certified teststo be negative for antibodies to HIV, HEP-B and THPA (syphilis).

Product description:
The extracellular matrix (ECM) is nature’s ideal environment for growth and cultivation of human cells. Especially basal membrane (BM) proteins modulate a wide range of fundamental key mechanisms in development, function and homeostasis of human cells. HUMAN PLACENTA Substrate (hpS) contains BM proteins such as laminin-111 as the major component (around 80-90%), collagen-IV (around 10%), bioactive growth factors, 0.4-0.8 IU thrombin/mL and other minor components. It contains 50 µg/mL Penstrep to prevent aerobic and anaerobic microbial growth. hpS is liquid and prepared at a concentration of 1,5 mg/mL. It does not gel at 37°C. However, addition of fibrinogen, collagen-I, or other polymers (e.g. F127) can be used for polymerization. HUVEC cells show vasculogenesis within two days when grown on hpS. PC-12 cells show neurite formation within two days when grown on hpS.

Precautions and Disclaimer:
This product is only for R&D use. Not for drug, household, or other uses. Please consult the Safety Data Sheet for information regarding hazards and safe handling procedures. Storage/Stability Delivery on dry ice. Following reconstitution, aliquot and freeze. Store hpS stock solutions at -20°C for up to 2 months, or -80°C for up to 12 months.

Storage/Stability:
Delivery on dry ice. Following reconstitution, aliquot and freeze. Store hpS stock solutions at 20°C for up to 2 months, or -80°C for up to 12 months

5 or 10 ml vials